Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.58 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.54 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037854 | 0.93 | EGFR (0.55) | EGFRFGFR3PAK1PKMYT1INSR | |
| SCHEMBL29037747 | 0.93 | EGFR (0.65) | EGFRFGFR3PAK1FGFR1FGFR2 | |
| SCHEMBL29037832 | 0.88 | EGFR (0.51) | EGFRFGFR3PAK1PKMYT1INSR | |
| SCHEMBL29037755 | 0.88 | SIK1 (0.52) | EGFRPAK1 | |
| SCHEMBL29037794 | 0.84 | EGFR (0.65) | EGFRFGFR3PAK1INSRIGF1R | |
| SCHEMBL29037715 | 0.83 | BTK (0.49) | EGFRPAK1FGFR1 | |
| SCHEMBL29037756 | 0.81 | EGFR (0.61) | EGFRFGFR3PAK1ALKFGFR1 | |
| SCHEMBL29037894 | 0.81 | PAK1 (0.61) | EGFRFGFR3PAK1ALKFGFR1 | |
| SCHEMBL30444439 | 0.81 | EGFR (0.61) | EGFRFGFR3PAK1ALKFGFR1 | |
| SCHEMBL29037691 | 0.80 | JAK3 (0.57) | EGFRPKMYT1INSRIGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |