Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | DPP4 | P27487 | 4/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2898009 | 0.99 | KCNA5 (0.65) | KCNA5KCNH2DPP4HTR6HTR2A | |
| SCHEMBL4685933 | 0.90 | KCNA5 (0.67) | KCNA5KCNH2DPP4MAPK8ACP1 | |
| SCHEMBL1381462 | 0.90 | KCNA5 (0.64) | KCNA5KCNH2DPP4HTR6MAPK8 | |
| Hydrochloric Acid SCHEMBL2904489 | 0.89 | KCNA5 (0.62) | KCNA5KCNH2DPP4HTR6MAPK8 | |
| SCHEMBL1378498 | 0.85 | KCNA5 (0.62) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL2900202 | 0.83 | KCNA5 (0.73) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| Hydrochloric Acid SCHEMBL2901589 | 0.82 | DPP4 (0.71) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL1379408 | 0.81 | KCNA5 (0.56) | KCNA5KCNH2DPP4MAPK8KDM4E | |
| SCHEMBL4685992 | 0.81 | KCNA5 (0.76) | KCNA5KCNH2DPP4MAPK8TACR1 | |
| SCHEMBL1382996 | 0.81 | KCNA5 (0.76) | KCNA5KCNH2DPP4MAPK8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667976-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | claimed |
| US-7741322-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-22 | — | — | US | claimed |
| US-20060281743-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-12-14 | — | — | US | claimed |
| EP-1667976-B1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | disclosed |
| US-7741322-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741322-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741322-B2 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1667976-A4 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2008-02-13 | — | — | EP | disclosed |
| US-20060281743-A1 | Isoquinolinone potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2006-12-14 | — | — | US | disclosed |
| EP-1667976-A1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030726-A1 | ISOQUINOLINONE POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281743-A1 | Isoquinolinone potassium channel inhibitors | KCNJ2, KCNQ1, KCNQ2 | KCNA5 23/4885KCNH2 4/4885DPP4 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.