Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542623 | 0.86 | MKNK1 (0.53) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL29048360 | 0.83 | MKNK2 (0.40) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL30701116 | 0.83 | MKNK2 (0.40) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL17553691 | 0.81 | MKNK2 (0.41) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL29419125 | 0.77 | MKNK1 (0.50) | MKNK2MKNK1DYRK1ACDK2EGFR | |
| SCHEMBL5096322 | 0.77 | MKNK1 (0.50) | MKNK2MKNK1DYRK1ACDK2EGFR | |
| SCHEMBL19254498 | 0.77 | GSK3B (0.48) | MKNK2MKNK1DYRK1ACDK2DYRK1B | |
| SCHEMBL17542604 | 0.76 | MKNK2 (0.53) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL22510211 | 0.76 | GSK3B (0.42) | MKNK2MKNK1DYRK1ACA12CA1 | |
| SCHEMBL22585743 | 0.75 | EGFR (0.49) | MKNK2MKNK1GSK3BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |