Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aceclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.71 |
| ▸ | TTR | P02766 | 3/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.71 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.71 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.71 |
| ▸ | ALB | P02768 | 1/20 | 0.71 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.71 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.71 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aceclofenac SCHEMBL29364020 | 0.99 | TTR (1.00) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL25734 | 0.99 | TTR (1.00) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL27918955 | 0.97 | TTR (0.97) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL16697727 | 0.97 | TTR (0.97) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL28443210 | 0.97 | TTR (0.97) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL5081852 | 0.96 | TTR (0.95) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL15268397 | 0.96 | TTR (0.95) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL28873275 | 0.96 | TTR (0.95) | TTRCYP2C9USP2LMNATBXA2R | |
| Aceclofenac SCHEMBL29775490 | 0.92 | TTR (0.86) | TTRCYP2C9USP2LMNATBXA2R | |
| SCHEMBL26655544 | 0.88 | TTR (0.80) | TTRCYP2C9USP2LMNATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814517-B1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LTD (IN) | 2010-08-11 | — | — | EP | claimed |
| CN-101530406-A | Compound enteric-coated preparation and preparation method thereof | JEWIM PHARMACEUTICAL SHANDONG | 2009-09-16 | — | — | CN | claimed |
| US-20090156670-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LIMITED (IN) | 2009-06-18 | — | — | US | claimed |
| CN-101060832-A | Nonaqueous liquid parenteral aceclofenac formulations | VENUS REMEDIES LTD (IN) | 2007-10-24 | — | — | CN | claimed |
| EP-1814517-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | Venus Remedies Limited (IN) | 2007-08-08 | — | — | EP | claimed |
| WO-2006054315-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LIMITED (IN) | 2006-05-26 | — | — | WO | claimed |
| CN-106822545-A | It is a kind of to treat time drug composition of knee osteoarthritis and preparation method thereof | 宁夏医科大学总医院 | 2017-06-13 | — | — | CN | disclosed |
| EP-2583674-B1 | ACECLOFENAC SLOW-RELEASE PREPARATION PROVIDING AN OPTIMUM PHARMACOLOGICAL CLINICAL EFFECT WHEN ADMINISTERED ONCE A DAY | KOREA UNITED PHARM INC (KR) | 2015-11-18 | — | — | EP | disclosed |
| EP-1814517-B1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LTD (IN) | 2010-08-11 | — | — | EP | disclosed |
| CN-101530406-A | Compound enteric-coated preparation and preparation method thereof | JEWIM PHARMACEUTICAL SHANDONG | 2009-09-16 | — | — | CN | disclosed |
| US-20090156670-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LIMITED (IN) | 2009-06-18 | — | — | US | disclosed |
| CN-101060832-A | Nonaqueous liquid parenteral aceclofenac formulations | VENUS REMEDIES LTD (IN) | 2007-10-24 | — | — | CN | disclosed |
| EP-1814517-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | Venus Remedies Limited (IN) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006054315-A1 | NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION | VENUS REMEDIES LIMITED (IN) | 2006-05-26 | — | — | WO | disclosed |