Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 6/20 | 0.45 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468487 | 1.00 | CLK2 (0.53) | CLK2AURKBCLK4PTK2PTK2B | |
| SCHEMBL13055175 | 0.84 | PTK2 (0.57) | PTK2PTK2B | |
| SCHEMBL29709931 | 0.80 | ALK (0.57) | PTK2TYK2METALK | |
| SCHEMBL22518895 | 0.80 | ALK (0.57) | PTK2TYK2METALK | |
| SCHEMBL12998546 | 0.79 | PTK2 (0.77) | PTK2PTK2BMETALK | |
| SCHEMBL29051782 | 0.75 | PTK2 (0.50) | AURKBPTK2PTK2BJAK2TYK2 | |
| SCHEMBL29051725 | 0.74 | PTK2 (0.58) | PTK2PTK2B | |
| SCHEMBL19831479 | 0.74 | ALK (0.42) | PTK2JAK2JAK3JAK1AURKA | |
| SCHEMBL17971184 | 0.73 | PTK2 (0.58) | PTK2PTK2B | |
| SCHEMBL29833117 | 0.73 | PDE2A (0.41) | PTK2PTK2BJAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |