Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 19/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | STK16 | O75716 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FER | P16591 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | ERCC2 | P18074 | 2/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052414 | 0.92 | PTK2 (0.47) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29052389 | 0.82 | PTK2 (0.52) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29051766 | 0.80 | PTK2 (0.50) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29051770 | 0.79 | PTK2 (0.48) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29051894 | 0.79 | PTK2 (0.51) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29051789 | 0.79 | WEE1 (0.45) | PTK2WEE1INSRALKMET | |
| SCHEMBL29051814 | 0.79 | ALK (0.49) | PTK2INSRALK | |
| SCHEMBL30468423 | 0.78 | PTK2 (0.54) | PTK2PTK2BAURKAJAK2STK16 | |
| Hydrochloric Acid SCHEMBL29051834 | 0.77 | PTK2 (0.53) | PTK2PTK2BAURKAJAK2STK16 | |
| SCHEMBL29051916 | 0.77 | STK17B (0.46) | PTK2PTK2BAURKAJAK2STK16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332910-A | 2-aminopyrimidine derivatives as kinase inhibitors, preparation and use thereof | 江苏威凯尔医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |