Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.60 |
| ▸ | KIT | P10721 | 7/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080208 | 1.00 | ENPP1 (0.60) | ENPP1KITPDE4APDE4BPDE4C | |
| SCHEMBL183550 | 0.86 | PIK3CD (0.62) | ENPP1KITPDE4APDE4BPDE4C | |
| SCHEMBL5569427 | 0.84 | KIT (0.58) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23726135 | 0.81 | KIT (0.57) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30079943 | 0.81 | KIT (0.57) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30080096 | 0.80 | ENPP1 (0.69) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23726401 | 0.80 | ENPP1 (0.69) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL6179414 | 0.79 | KIT (0.59) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23727016 | 0.78 | PDE10A (0.59) | ENPP1KITPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30080146 | 0.78 | PDE10A (0.59) | ENPP1KITPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115362145-A | Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) inhibitors and methods of use thereof | 斯汀格瑞治疗股份有限公司 | 2022-11-18 | — | — | CN | disclosed |