Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 9/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080166 | 1.00 | ENPP1 (0.84) | ENPP1PDGFRBSRCABL1EGFR | |
| SCHEMBL30080157 | 0.95 | ENPP1 (0.76) | ENPP1PDGFRBSRCABL1EGFR | |
| SCHEMBL29055078 | 0.95 | ENPP1 (0.76) | ENPP1PDGFRBSRCABL1EGFR | |
| SCHEMBL23727241 | 0.91 | ENPP1 (1.00) | ENPP1PDGFRBSRC | |
| SCHEMBL30117251 | 0.91 | ENPP1 (1.00) | ENPP1PDGFRBSRC | |
| SCHEMBL30117257 | 0.87 | ENPP1 (0.91) | ENPP1PDGFRB | |
| SCHEMBL23726534 | 0.87 | ENPP1 (0.91) | ENPP1PDGFRB | |
| SCHEMBL30080080 | 0.83 | ENPP1 (0.58) | ENPP1 | |
| SCHEMBL25656154 | 0.81 | ENPP1 (0.80) | ENPP1PDGFRBSRC | |
| SCHEMBL30080198 | 0.79 | ENPP1 (0.52) | ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115362145-A | Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) inhibitors and methods of use thereof | 斯汀格瑞治疗股份有限公司 | 2022-11-18 | — | — | CN | disclosed |