Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.63 |
| ▸ | MTOR | P42345 | 17/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.59 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.59 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.59 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.59 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907747 | 0.92 | KCNH2 (0.65) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2905856 | 0.89 | MTOR (0.65) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2906937 | 0.87 | MTOR (0.66) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2906198 | 0.87 | MTOR (0.67) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2903104 | 0.87 | MTOR (0.62) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2907372 | 0.86 | MTOR (0.77) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2901168 | 0.86 | MTOR (0.77) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2908278 | 0.85 | MTOR (0.64) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2905736 | 0.84 | MTOR (0.78) | KCNH2MTORPIK3CDPIK3CARICTOR | |
| SCHEMBL2907632 | 0.83 | MTOR (0.62) | KCNH2MTORPIK3CDPIK3CARICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217234-A2 | COMBINATIONS OF MEK INHIBITORS WITH MTOR INHIBITORS | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009050506-A2 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | WO | disclosed |