SCHEMBL29059583

SCHEMBL29059583

O=C(Nc1scc(-c2ccc(Cl)cc2)c1C(=O)O)c1cc(Cl)ccc1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ANO1 Q5XXA6 20/20 1.00
ANO2 Q9NQ90 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29059724 0.92 ANO1 (1.00) ANO1ANO2
SCHEMBL29059727 0.88 ANO1 (1.00) ANO1ANO2
SCHEMBL30489873 0.87 ANO1 (1.00) ANO1ANO2
SCHEMBL29059731 0.87 ANO1 (1.00) ANO1ANO2
SCHEMBL28595212 0.87 ANO1 (1.00) ANO1ANO2
SCHEMBL30489870 0.86 ANO1 (1.00) ANO1ANO2
SCHEMBL29059753 0.86 ANO1 (1.00) ANO1ANO2
SCHEMBL29059776 0.86 ANO1 (1.00) ANO1ANO2
SCHEMBL30489869 0.85 ANO1 (1.00) ANO1ANO2
SCHEMBL29059770 0.85 ANO1 (1.00) ANO1ANO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116444481-A 4-arylthiophene carboxylic acid compounds as ANO1 protein inhibitors 北京大学 2023-07-18 CN claimed
CN-116444481-A 4-arylthiophene carboxylic acid compounds as ANO1 protein inhibitors 北京大学 2023-07-18 CN disclosed