Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | INSR | P06213 | 8/20 | 0.52 |
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059787 | 0.92 | ALK (0.58) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059680 | 0.91 | ALK (0.56) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL30497508 | 0.90 | EGFR (0.65) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25872878 | 0.90 | EGFR (0.65) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059839 | 0.90 | ALK (0.56) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059652 | 0.87 | ALK (0.57) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059833 | 0.86 | ALK (0.51) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059672 | 0.86 | ALK (0.58) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059802 | 0.86 | ALK (0.58) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL29059684 | 0.85 | EGFR (0.62) | ALKEGFRINSRIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490184-A | Compounds for inhibiting EGFR mutant cancers and pharmaceutical uses thereof | J2H生物科技有限公司 | 2023-07-25 | — | — | CN | disclosed |