Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214973 | 0.94 | — | — | |
| SCHEMBL1461150 | 0.94 | — | — | |
| Acetaldehyde SCHEMBL11218187 | 0.83 | TP53 (0.36) | HTTTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL6982942 | 0.81 | HTT (0.42) | HTTALDH1A1MAPTADAMTS4MEN1 | |
| SCHEMBL17906185 | 0.74 | MME (0.47) | LMNASMN1; SMN2MMELTA4HANPEP | |
| SCHEMBL2807366 | 0.71 | TP53 (0.47) | TP53ADAMTS4MME | |
| SCHEMBL3808901 | 0.71 | TP53 (0.47) | TP53ADAMTS4MME | |
| SCHEMBL4572684 | 0.71 | TP53 (0.47) | TP53ADAMTS4MME | |
| SCHEMBL109878 | 0.71 | TP53 (0.47) | TP53ADAMTS4MME | |
| SCHEMBL4572680 | 0.71 | TP53 (0.47) | TP53ADAMTS4MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109906222-B | Allosteric corticotropin releasing factor receptor 1 (CRFR 1) antagonists that reduce P-TAU and improve cognition | 加利福尼亚大学董事会 | 2023-08-01 | — | — | CN | disclosed |