Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | MAP2 | P11137 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29062921 | 0.86 | IDO1 (0.48) | CCNCCDK8MAP2KMT2AATM | |
| SCHEMBL3959096 | 0.83 | EIF4A3 (0.53) | KMT2ARHEBKDM4EEIF4A3ALDH1A1 | |
| SCHEMBL30310764 | 0.83 | EIF4A3 (0.53) | KMT2ARHEBKDM4EEIF4A3ALDH1A1 | |
| SCHEMBL29062784 | 0.82 | KDM4E (0.57) | CCNCCDK8MAP2KMT2ARHEB | |
| SCHEMBL8319918 | 0.77 | GLA (0.48) | KDM4EFBP1ALDH1A1CDK1CCNB1 | |
| SCHEMBL20504857 | 0.76 | EIF4A3 (0.50) | CCNCCDK8MAP2RHEBMAP2K1 | |
| SCHEMBL30310556 | 0.75 | HRH4 (0.56) | CCNCCDK8MAP2KMT2AKDM4E | |
| SCHEMBL20505087 | 0.75 | FLT3 (0.57) | MAP2KMT2ARHEBNUDT1KDM4E | |
| SCHEMBL29063451 | 0.75 | HRH4 (0.56) | CCNCCDK8MAP2KMT2AKDM4E | |
| SCHEMBL26912440 | 0.75 | CCNC (0.40) | CCNCCDK8KMT2ARHEBMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116685576-A | Cysteine protease inhibitors and methods of use thereof | 美商帕迪斯生物科学公司 | 2023-09-01 | — | — | CN | disclosed |
| EP-4161902-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |