Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203239 | 0.91 | FYN (0.51) | FYNPIM1HDAC1NTRK1CLK1 | |
| SCHEMBL1203328 | 0.91 | FYN (0.55) | FYNPIM1HDAC1NTRK1CLK1 | |
| SCHEMBL1203735 | 0.91 | FYN (0.52) | FYNPIM1HDAC1NTRK1CLK1 | |
| SCHEMBL1203488 | 0.90 | FYN (0.52) | FYNPIM1NTRK1CLK1ALDH1A1 | |
| SCHEMBL1203065 | 0.89 | PPARA (0.54) | FYNPIM1HDAC1NTRK1 | |
| SCHEMBL1202563 | 0.89 | MEN1 (0.53) | FYNPIM1HDAC1NTRK1ALDH1A1 | |
| SCHEMBL1202181 | 0.87 | FYN (0.49) | FYNPIM1HDAC1NTRK1VNN1 | |
| SCHEMBL1203600 | 0.86 | FYN (0.59) | FYNPIM1NTRK1CLK1VNN1 | |
| SCHEMBL1202889 | 0.86 | PIM1 (0.50) | FYNPIM1HDAC1NTRK1VNN1 | |
| SCHEMBL2943172 | 0.84 | FYN (0.69) | FYNPIM1NTRK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |