Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.67 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL10346457 | 1.00 | GSR (0.67) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL23162476 | 1.00 | GSR (0.67) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL3062914 | 1.00 | GSR (0.67) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL10346746 | 0.97 | GSR (0.62) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL17112858 | 0.97 | GSR (0.62) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL9751560 | 0.97 | GSR (0.62) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL2934512 | 0.95 | GSR (0.74) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL21494161 | 0.95 | GSR (0.74) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL429888 | 0.95 | GSR (0.74) | GSRSLC7A5ARG2ARG1NOS2 | |
| Lysine SCHEMBL429887 | 0.95 | GSR (0.74) | GSRSLC7A5ARG2ARG1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116568698-A | Linker compounds comprising an amide bond | MPEG LA有限责任公司 | 2023-08-08 | — | — | CN | disclosed |