Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC2 | Q13490 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.35 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16826797 | 0.89 | BIRC2 (0.38) | BIRC2PLA2G10PLA2G5SIGMAR1NR1H2 | |
| SCHEMBL16854473 | 0.89 | BIRC2 (0.38) | BIRC2PLA2G10PLA2G5SIGMAR1NR1H2 | |
| SCHEMBL4960304 | 0.82 | BIRC2 (0.35) | BIRC2PLA2G10PLA2G5SIGMAR1MAPT | |
| SCHEMBL17153062 | 0.81 | BIRC2 (0.55) | BIRC2PLA2G10PLA2G5 | |
| SCHEMBL17153080 | 0.78 | BIRC2 (0.37) | BIRC2PLA2G10PLA2G5SIGMAR1MAPT | |
| SCHEMBL20296671 | 0.78 | CA1 (0.45) | CA1CA2CA4CA9NR1H2 | |
| SCHEMBL14720039 | 0.78 | CA1 (0.45) | CA1CA2CA4CA9NR1H2 | |
| SCHEMBL12836933 | 0.78 | CA1 (0.45) | CA1CA2CA4CA9NR1H2 | |
| SCHEMBL17153059 | 0.77 | BIRC2 (0.38) | BIRC2PLA2G10PLA2G5SIGMAR1 | |
| SCHEMBL28853916 | 0.76 | BIRC2 (0.37) | BIRC2CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132777-A2 | TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS | ACHAOGEN, INC. (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132770-A1 | TREATMENT OF KLEBSIELLA PNEUMONIAE INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS | ACHAOGEN, INC. (US) | 2010-11-18 | — | — | WO | disclosed |
| EP-2217610-A1 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | Achaogen, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009067692-A1 | ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS | ACHAOGEN, INC. (US) | 2009-05-28 | — | — | WO | disclosed |