Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd-7451. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 known ✓ | P04629 | 20/20 | 0.72 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | FGR | P09769 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | SIK1 | P57059 | 1/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | ITK | Q08881 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.53 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-7451 SCHEMBL29073123 | 1.00 | NTRK1 (0.72) | NTRK1JAK2ALKABL1FGR | |
| Azd-7451 SCHEMBL29690374 | 1.00 | NTRK1 (0.72) | NTRK1JAK2ALKABL1FGR | |
| Azd-7451 SCHEMBL29690227 | 0.95 | NTRK1 (0.76) | NTRK1JAK2ALKABL1FGR | |
| Azd-7451 SCHEMBL3769178 | 0.95 | NTRK1 (0.76) | NTRK1JAK2ALKABL1FGR | |
| Azd-7451 SCHEMBL18797141 | 0.95 | NTRK1 (0.76) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL3773386 | 0.85 | NTRK1 (0.75) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL3775459 | 0.85 | NTRK1 (0.60) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL3777718 | 0.84 | NTRK1 (0.77) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL3773405 | 0.84 | NTRK1 (1.00) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL3705688 | 0.83 | NTRK1 (0.59) | NTRK1JAK2ALKABL1FGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116782883-A | Topical pharmaceutical compositions and methods | 金字塔生物科技公司 | 2023-09-19 | — | — | CN | disclosed |