Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 16/20 | 0.66 |
| ▸ | ELOC | Q15369 | 5/20 | 0.48 |
| ▸ | ELOB | Q15370 | 5/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29073319 | 0.92 | VHL (0.66) | VHLELOCELOB | |
| SCHEMBL30570906 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL24438218 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL26909817 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL24438430 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL24438222 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL30570894 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL30570898 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL26909876 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 | |
| SCHEMBL26909821 | 0.91 | VHL (0.72) | VHLELOCELOBDPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783183-A | 1- (2- (4-cyclopropyl-1H-1, 2, 3-triazol-1-yl) acetyl) -4-hydroxy-N- (benzyl) pyrrolidine-2-carboxamide derivatives as VHL inhibitors for the treatment of anemia and cancer | 基因泰克公司 | 2023-09-19 | — | — | CN | disclosed |