Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | CLK2 | P49760 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 12/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912689 | 0.89 | CDK2 (0.49) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2912755 | 0.88 | CDK2 (0.50) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2912806 | 0.87 | CDK2 (0.46) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2905018 | 0.85 | CDK2 (0.64) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2907818 | 0.85 | CDK2 (0.49) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2908783 | 0.84 | CDK2 (0.48) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2912355 | 0.82 | CDK2 (0.48) | CDK2CCNA2CDK4CDK5CDK1 | |
| SCHEMBL2912973 | 0.82 | CDK2 (0.38) | CDK2CCNA2CDK5CDK1CCNB1 | |
| SCHEMBL2911898 | 0.81 | CDK2 (0.44) | CDK2CDK5CDK1CCNB1CDK5R1 | |
| SCHEMBL2911079 | 0.81 | CDK2 (0.57) | CDK2CCNA2CDK4CDK5CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |