Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | SIK1 | P57059 | 2/20 | 0.47 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.47 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.40 |
| ▸ | MERTK | Q12866 | 5/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31612077 | 1.00 | LCK (0.48) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL29076325 | 0.96 | LCK (0.49) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612102 | 0.96 | LCK (0.49) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612068 | 0.92 | LCK (0.52) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL29076331 | 0.92 | LCK (0.52) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612105 | 0.89 | LCK (0.60) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL29076139 | 0.89 | LCK (0.60) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612087 | 0.88 | SIK1 (0.58) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612115 | 0.88 | LCK (0.51) | LCKMAPK14SIK1SIK2SIK3 | |
| SCHEMBL31612106 | 0.88 | LCK (0.53) | LCKMAPK14SIK1SIK2SIK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514726-A | Pyrimidine derivative and application thereof | 四川大学 | 2023-08-01 | — | — | CN | disclosed |