SCHEMBL2907629

SCHEMBL2907629

N=C(NN)N[C@H]1CN2CCC1CC2

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.51
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA9 Q16790 3/20 0.51
CHRNA7 P36544 7/20 0.43
HTR3E A5X5Y0 4/20 0.42
HTR3B O95264 4/20 0.42
HTR3A P46098 4/20 0.42
HTR3D Q70Z44 4/20 0.42
HTR3C Q8WXA8 4/20 0.42
ALOX15 P16050 1/20 0.42
TSHR P16473 1/20 0.42
CHRM2 P08172 2/20 0.40
CHRM1 P11229 2/20 0.40
CHRM3 P20309 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2902377 1.00 CA12 (0.51) CA12CA1CA2CA9CHRNA7
Iodide SCHEMBL4006800 0.98 CA12 (0.50) CA12CA1CA2CA9CHRNA7
Iodide SCHEMBL4001434 0.98 CA12 (0.50) CA12CA1CA2CA9CHRNA7
SCHEMBL2745668 0.81 CA12 (0.55) CA12CA1CA2CA9CHRNA7
SCHEMBL10165806 0.81 CA12 (0.55) CA12CA1CA2CA9CHRNA7
SCHEMBL10165807 0.81 CA12 (0.55) CA12CA1CA2CA9CHRNA7
Hydrochloric Acid SCHEMBL2745487 0.79 CA12 (0.53) CA12CA1CA2CA9CHRNA7
Hydrochloric Acid SCHEMBL2745607 0.79 CA12 (0.53) CA12CA1CA2CA9CHRNA7
Hydrochloric Acid SCHEMBL2745182 0.79 CA12 (0.53) CA12CA1CA2CA9CHRNA7
SCHEMBL10166061 0.77 CA12 (0.55) CA12CA1CA2CA9CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874761-B1 4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS AVENTIS PHARMA SA (FR) 2010-08-18 EP disclosed
EP-1874761-A2 4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS Aventis Pharma S.A. (FR) 2008-01-09 EP disclosed
WO-2006111662-A2 4H-1,2,4-TRIAZIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS AVENTIS PHARMA S.A. (FR) 2006-10-26 WO disclosed