Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540811 | 0.87 | PDE5A (0.57) | PDE5APIK3CBPIK3CDPIK3CARAF1 | |
| SCHEMBL290767 | 0.86 | PDE5A (0.56) | PDE5APIK3CBPIK3CDPIK3CARAF1 | |
| SCHEMBL2680916 | 0.83 | PDE5A (0.54) | PDE5APIK3CBPIK3CDPIK3CAALDH1A1 | |
| SCHEMBL27937567 | 0.80 | PDE5A (0.55) | PDE5AALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL20559620 | 0.80 | PDE5A (0.76) | PDE5APIK3CBPIK3CDPIK3CAALDH1A1 | |
| SCHEMBL298995 | 0.80 | PDE5A (0.49) | PDE5APIK3CBPIK3CDPIK3CAALDH1A1 | |
| SCHEMBL27950957 | 0.79 | PDE5A (0.58) | PDE5AALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2681006 | 0.77 | PDE5A (0.57) | PDE5AALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL291120 | 0.77 | PDE5A (0.76) | PDE5AALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL26647595 | 0.76 | HTT (0.48) | PDE5APIK3CBPIK3CDPIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024038089-A1 | USE OF A THERAPEUTIC AGENT WITH PHOSPHODIESTERASE-7 INHIBITORY ACTIVITY FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH CHRONIC FATIGUE, EXHAUSTION AND/OR EXERTIONAL INTOLERANCE | MITODICURE GMBH (DE) | 2024-02-22 | — | — | WO | disclosed |
| EP-2427193-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | Omeros Corporation (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129036-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION (US) | 2010-11-11 | — | — | WO | disclosed |