Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.52 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290829 | 0.91 | PDE5A (0.68) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL291191 | 0.88 | PDE5A (0.69) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL6068491 | 0.88 | PDE5A (0.69) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL5530361 | 0.86 | PDE5A (0.71) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL6068427 | 0.86 | PDE5A (0.71) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL291826 | 0.86 | PDE5A (0.66) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL290818 | 0.84 | PDE5A (0.66) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL291097 | 0.84 | PDE5A (0.68) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL290819 | 0.84 | PDE5A (0.68) | PDE5APDE3BPDE3APDE2AALDH1A1 | |
| SCHEMBL6068634 | 0.83 | PDE5A (0.63) | PDE5APDE3BPDE3APDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427193-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | Omeros Corporation (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129036-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS | OMEROS CORPORATION (US) | 2010-11-11 | — | — | WO | disclosed |