SCHEMBL29088937

SCHEMBL29088937

C[C@@H](COCCCC(=O)O)Nc1cn[nH]c(=O)c1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TIPARP Q7Z3E1 20/20 0.59
PARP1 P09874 1/20 0.59
CYP2C9 P11712 1/20 0.59
PARP14 Q460N5 1/20 0.59
PARP16 Q8N5Y8 1/20 0.59
PARP12 Q9H0J9 1/20 0.59
TNKS2 Q9H2K2 1/20 0.59
PARP11 Q9NR21 1/20 0.59
PARP2 Q9UGN5 1/20 0.59
PARP4 Q9UKK3 1/20 0.59
PARP3 Q9Y6F1 1/20 0.59
HDAC6 Q9UBN7 12/20 0.57
HDAC1 Q13547 11/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21521497 0.94 TIPARP (0.64) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL21521770 0.94 TIPARP (0.64) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL21521495 0.94 TIPARP (0.64) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL24954326 0.87 TIPARP (0.57) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL21521530 0.86 TIPARP (0.63) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL21522323 0.86 TIPARP (0.63) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL21521528 0.86 TIPARP (0.63) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL24640862 0.85 TIPARP (0.58) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL24467690 0.84 TIPARP (0.57) TIPARPPARP1CYP2C9PARP14PARP16
SCHEMBL29274231 0.84 TIPARP (0.55) TIPARPPARP1CYP2C9PARP14PARP16

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116724044-A Tri-heterocyclic compound, preparation method and application thereof 上海湃隆生物科技有限公司 2023-09-08 CN disclosed