Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 13/20 | 1.00 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.77 |
| ▸ | EZH1 | Q92800 | 2/20 | 0.77 |
| ▸ | EED | O75530 | 1/20 | 0.77 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.77 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.77 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.77 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29093621 | 0.99 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093649 | 0.98 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093703 | 0.93 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093613 | 0.93 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093606 | 0.93 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093635 | 0.93 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093837 | 0.93 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093625 | 0.92 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL29093708 | 0.91 | HDAC6 (1.00) | HDAC6HDAC1EZH2EZH1EED | |
| SCHEMBL21285007 | 0.88 | HDAC6 (0.79) | HDAC6HDAC1EZH2EZH1EED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768857-A | EZH2/HDAC double-target inhibitor and preparation method and medical application thereof | 中国药科大学 | 2023-09-19 | — | — | CN | claimed |
| CN-116768857-A | EZH2/HDAC double-target inhibitor and preparation method and medical application thereof | 中国药科大学 | 2023-09-19 | — | — | CN | disclosed |