Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dodine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334088 | 0.79 | EBP (0.56) | EBPSIGMAR1KDM4EALDH1A1TDP1 | |
| SCHEMBL2334083 | 0.79 | EBP (0.56) | EBPSIGMAR1KDM4EALDH1A1TDP1 | |
| Dodine SCHEMBL22124 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Acetic Acid SCHEMBL2905260 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Acetic Acid SCHEMBL29256286 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Dodine SCHEMBL9055972 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Dodine SCHEMBL9766434 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Acetic Acid SCHEMBL2905199 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Acetic Acid SCHEMBL3289314 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 | |
| Acetic Acid SCHEMBL9054431 | 0.79 | EPHX1 (0.55) | KDM4ESPHK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116941624-A | Sterilization insecticidal composition and application thereof | 山东省联合农药工业有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-115251064-B | Sterilization insecticidal composition and application thereof | 山东省联合农药工业有限公司 | 2023-08-29 | — | — | CN | disclosed |