Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23983444 | 0.82 | DDB1 (0.47) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL24678268 | 0.80 | CRBN (0.50) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL24671496 | 0.79 | DDB1 (0.56) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL24678273 | 0.79 | CRBN (0.51) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL29794453 | 0.78 | DDB1 (0.50) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL8805370 | 0.77 | SLC6A4 (0.53) | CRBNALDH1A1USP2 | |
| SCHEMBL28961409 | 0.77 | DDB1 (0.47) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL22119568 | 0.77 | CRBN (0.64) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL25170633 | 0.77 | CRBN (0.59) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL23983294 | 0.76 | CRBN (0.55) | DDB1CRBNALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116981675-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2023-10-31 | — | — | CN | disclosed |