Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29098530 | 0.96 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30312891 | 0.92 | CRBN (0.52) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL27091569 | 0.90 | CRBN (0.54) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25813731 | 0.88 | CRBN (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24123319 | 0.87 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31461798 | 0.87 | CRBN (0.59) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30312892 | 0.87 | CRBN (0.51) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24817881 | 0.86 | DDB1 (0.60) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22326198 | 0.86 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22326301 | 0.86 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| CN-115605488-A | Bifunctional degradants of hematopoietic progenitor kinases and therapeutic uses thereof | 新锐思生物制药股份有限公司（US） | 2023-01-13 | — | — | CN | disclosed |