Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30185565 | 1.00 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099564 | 1.00 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099550 | 0.82 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099575 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099574 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185577 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099530 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL30185588 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099537 | 0.81 | PIK3CA (0.63) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL29099560 | 0.81 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611883-A | PI3K alpha inhibitor with bicyclic structure and preparation method and application thereof | 生物岛实验室 | 2023-01-17 | — | — | CN | disclosed |