Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.34 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910784 | 0.87 | CRBN (0.41) | CRBNCYP3A4 | |
| SCHEMBL1530844 | 0.85 | CRBN (0.54) | CRBNCYP3A4PIK3CGSMN1; SMN2PIK3CD | |
| SCHEMBL3105519 | 0.83 | CRBN (0.42) | CRBNCYP3A4 | |
| SCHEMBL2913314 | 0.83 | CRBN (0.42) | CRBNCYP3A4 | |
| SCHEMBL2909603 | 0.82 | CRBN (0.42) | CRBNCYP3A4GAAHPGD | |
| SCHEMBL2913952 | 0.82 | CRBN (0.40) | CRBNCYP3A4ALDH1A1 | |
| SCHEMBL478603 | 0.81 | CRBN (0.42) | CRBNCYP3A4 | |
| SCHEMBL2907207 | 0.78 | CRBN (0.39) | CRBNCYP3A4 | |
| SCHEMBL2913914 | 0.74 | CRBN (0.42) | CRBNCYP3A4SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2907834 | 0.74 | CRBN (0.35) | CRBNCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |