Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15007793 | 0.99 | KDM4E (0.37) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| Bromide SCHEMBL7046232 | 0.90 | CNR2 (0.37) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL7044297 | 0.88 | CNR2 (0.38) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| Bromide SCHEMBL28382629 | 0.85 | MAPT (0.40) | KDM4EMAPTKMT2AALDH1A1GLA | |
| Bromide SCHEMBL14958491 | 0.85 | MAPT (0.40) | KDM4EMAPTKMT2AALDH1A1GLA | |
| Bromide SCHEMBL14958504 | 0.84 | TLR8 (0.39) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL1306089 | 0.83 | MAPT (0.41) | KDM4EMAPTKMT2AALDH1A1GLA | |
| SCHEMBL28685784 | 0.83 | ELANE (0.37) | KDM4EMAPTMEN1KMT2AMAPK1 | |
| Iodide SCHEMBL28381275 | 0.82 | MAPT (0.40) | KDM4EMAPTKMT2AALDH1A1GLA | |
| Bromide SCHEMBL14958495 | 0.82 | HRH3 (0.33) | KDM4EMAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117092077-A | Visual fluorescent test paper for detecting sulfur dioxide and derivatives thereof, and preparation method and application thereof | 广东工业大学 | 2023-11-21 | — | — | CN | disclosed |
| CN-117024442-A | Targeting lysosomes, pH activated SO 2 Fluorescent probe and preparation and application thereof | 广东工业大学 | 2023-11-10 | — | — | CN | disclosed |