Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 3/20 | 0.43 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29961330 | 1.00 | MAPT (0.46) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL29115549 | 1.00 | MAPT (0.46) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL29960900 | 1.00 | MAPT (0.46) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL29115460 | 1.00 | MAPT (0.46) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL531966 | 0.85 | MAPT (0.53) | MAPTALDH1A1HPGDTSHRRAB9A | |
| Hydrochloric Acid SCHEMBL708105 | 0.84 | MAPT (0.52) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL719372 | 0.83 | MAPT (0.50) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL29960627 | 0.82 | MAPT (0.47) | MAPTALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL29115582 | 0.82 | MAPT (0.47) | MAPTALDH1A1HPGDTSHRRAB9A | |
| Hydrochloric Acid SCHEMBL710508 | 0.82 | MAPT (0.49) | MAPTALDH1A1HPGDTSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710433-A | Selective PARP1 inhibitor and application thereof | 成都百裕制药股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022222966-A1 | SELECTIVE PARP1 INHIBITOR AND APPLICATION THEREOF | 成都百裕制药股份有限公司 | 2022-10-27 | — | — | WO | disclosed |