Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908679 | 0.90 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL2914771 | 0.87 | HRH3 (0.48) | HRH3KCNH2 | |
| SCHEMBL525059 | 0.84 | HRH3 (0.66) | HRH3KCNH2 | |
| SCHEMBL3657328 | 0.84 | HRH3 (0.66) | HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL523998 | 0.84 | HRH3 (0.64) | HRH3KCNH2 | |
| SCHEMBL3661875 | 0.82 | HRH3 (0.60) | HRH3KCNH2 | |
| SCHEMBL524645 | 0.82 | HRH3 (0.63) | HRH3KCNH2 | |
| SCHEMBL4130243 | 0.82 | HRH3 (0.62) | HRH3KCNH2 | |
| SCHEMBL524424 | 0.81 | HRH3 (0.65) | HRH3KCNH2 | |
| SCHEMBL3659596 | 0.81 | HRH3 (0.60) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222650-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-09-01 | — | — | EP | claimed |
| WO-2009067405-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-28 | — | — | WO | claimed |
| US-20090131416-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-21 | — | — | US | claimed |
| WO-2009067405-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |
| US-20090131416-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-21 | — | — | US | disclosed |
| US-20090131416-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-21 | — | — | US | disclosed |
| US-20090131416-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131416-A1 | SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | HRH3 1/4885KCNH2 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.