SCHEMBL29119545

SCHEMBL29119545

Nc1ncnc2c1CCN2C1CC(/C=C/c2ccc3cc(Br)c(NCC4CC4)nc3c2)[C@@H](O)C1O

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 12/20 0.42
WDR77 Q9BQA1 6/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24953043 1.00 PRMT5 (0.42) PRMT5WDR77
SCHEMBL30159402 1.00 PRMT5 (0.42) PRMT5WDR77
SCHEMBL29119544 1.00 PRMT5 (0.42) PRMT5WDR77
SCHEMBL30159326 0.87 PRMT5 (0.48) PRMT5WDR77
SCHEMBL24954222 0.87 PRMT5 (0.48) PRMT5WDR77
SCHEMBL29119486 0.87 PRMT5 (0.48) PRMT5WDR77
SCHEMBL29119484 0.87 PRMT5 (0.48) PRMT5WDR77
SCHEMBL24954361 0.87 PRMT5 (0.31) PRMT5WDR77
SCHEMBL24953044 0.84 PRMT5 (0.30) PRMT5WDR77
SCHEMBL30159357 0.84 PRMT5 (0.30) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117157297-A PRMT5 inhibitors 上海齐鲁制药研究中心有限公司 2023-12-01 CN disclosed