Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29124184 | 1.00 | NR1H2 (0.48) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL20128951 | 0.89 | NR1H2 (0.51) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL18689925 | 0.81 | PRMT5 (0.46) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL31279449 | 0.81 | PRMT5 (0.46) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL8010277 | 0.79 | MEN1 (0.49) | NR1H2PRMT5WDR77PIK3CDMEN1 | |
| SCHEMBL20477490 | 0.79 | MEN1 (0.49) | NR1H2PRMT5WDR77PIK3CDMEN1 | |
| SCHEMBL31618562 | 0.78 | HPGD (0.46) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL31618749 | 0.78 | HPGD (0.46) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL1733959 | 0.78 | HPGD (0.48) | NR1H2PRMT5WDR77USP2SMN1; SMN2 | |
| SCHEMBL933025 | 0.78 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117229289-A | Preparation and application of EGFR inhibitor with macrocyclic structure | 药雅科技(上海)有限公司 | 2023-12-15 | — | — | CN | disclosed |