Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29127343 | 0.93 | JAK3 (0.44) | JAK3FGFR4EGFRBTKSRC | |
| SCHEMBL29127332 | 0.88 | PTGDR2 (0.37) | BMX | |
| SCHEMBL29127328 | 0.84 | ACKR3 (0.38) | JAK3EGFRBTKSRC | |
| SCHEMBL29127337 | 0.81 | BRD4 (0.39) | BTK | |
| SCHEMBL28887513 | 0.81 | JAK3 (0.56) | JAK3FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28887535 | 0.80 | JAK3 (0.57) | JAK3FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL29127340 | 0.79 | JAK2 (0.33) | JAK3SRC | |
| SCHEMBL28887562 | 0.77 | JAK3 (0.51) | JAK3EGFRBTK | |
| SCHEMBL28887539 | 0.77 | EGFR (0.45) | JAK3FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL28887565 | 0.75 | JAK3 (0.51) | JAK3FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |