Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.88 |
| ▸ | RAB9A | P51151 | 9/20 | 0.63 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30666651 | 1.00 | KDM4E (0.88) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2730201 | 0.93 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2730205 | 0.93 | KDM4E (1.00) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28538962 | 0.92 | KDM4E (0.97) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4745288 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL29644896 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL29690600 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL79427 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4745286 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7995904 | 0.87 | KDM4E (0.81) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116940552-A | Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors | 法国施维雅药厂 | 2023-10-24 | — | — | CN | disclosed |