Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907252 | 0.94 | GSK3B (0.44) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL1219461 | 0.86 | GSK3B (0.49) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2912808 | 0.85 | GSK3B (0.46) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2907714 | 0.85 | GSK3B (0.42) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL12892551 | 0.84 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2910831 | 0.84 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2904789 | 0.84 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2907075 | 0.84 | GSK3B (0.47) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2909927 | 0.84 | GSK3B (0.49) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2905325 | 0.83 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |