Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.75 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.75 |
| ▸ | CDK9 | P50750 | 5/20 | 0.75 |
| ▸ | CDK7 | P50613 | 4/20 | 0.75 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.75 |
| ▸ | CCNH | P51946 | 2/20 | 0.75 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.75 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | CCNK | O75909 | 2/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 8/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.49 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913193 | 0.86 | CDK2 (1.00) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2913185 | 0.86 | CDK2 (1.00) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2913009 | 0.84 | CDK2 (0.53) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2907511 | 0.81 | CDK2 (0.72) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2907521 | 0.81 | CDK2 (0.72) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2907920 | 0.77 | CDK1 (0.81) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2908697 | 0.71 | CDK2 (0.52) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2908707 | 0.71 | CDK2 (0.52) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2912940 | 0.70 | CDK2 (0.51) | CDK2CCNE1CDK5CDK9CDK7 | |
| SCHEMBL2912923 | 0.70 | CDK2 (0.51) | CDK2CCNE1CDK5CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348707-B1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | USTAV EX BOTAN AV CR V V I I O (CZ) | 2010-08-25 | — | — | EP | disclosed |
| EP-1348707-A1 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) (CZ) | 2003-10-01 | — | — | EP | disclosed |