Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.35 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.34 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915591 | 0.90 | CRBN (0.52) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2911158 | 0.90 | CRBN (0.52) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2914093 | 0.90 | CRBN (0.52) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2913874 | 0.90 | CRBN (0.54) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2913931 | 0.88 | CRBN (0.69) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2915248 | 0.88 | CRBN (0.58) | CRBNBRPF1IKBKBCHUKBRD4 | |
| Water SCHEMBL2915433 | 0.88 | CRBN (0.68) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2319969 | 0.88 | CRBN (0.50) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2910644 | 0.87 | CRBN (0.49) | CRBNBRPF1IKBKBCHUKBRD4 | |
| SCHEMBL2913845 | 0.87 | CRBN (0.49) | CRBNBRD4PTK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2203431-A1 | ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039134-A1 | ANTI-INFECTIVE PYRIMIDINES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |