Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132084 | 0.88 | GRIN2B (0.47) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL23860580 | 0.85 | GRIN2B (0.49) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL29132210 | 0.85 | GRIN2B (0.48) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL29132144 | 0.80 | GRIN2B (0.43) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL25293557 | 0.80 | GRM5 (0.54) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL29132081 | 0.76 | SMN1; SMN2 (0.56) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL30812124 | 0.75 | GRIN2B (0.52) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL29132125 | 0.75 | SMN1; SMN2 (0.50) | GRIN2BCYP2D6CYP2C9CYP3A4SMN1; SMN2 | |
| SCHEMBL13661148 | 0.74 | SMN1; SMN2 (0.58) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH | |
| SCHEMBL6584365 | 0.74 | SMN1; SMN2 (0.62) | GRIN2BCYP2D6CYP2C9CYP3A4FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |