Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.69 |
| ▸ | AR | P10275 | 3/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29927679 | 0.96 | CRBN (0.71) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL20231272 | 0.96 | CRBN (0.71) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29132077 | 0.94 | CRBN (0.65) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29927274 | 0.94 | CRBN (0.65) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29927985 | 0.94 | CRBN (0.65) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29132341 | 0.94 | CRBN (0.65) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29132298 | 0.94 | CRBN (0.65) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29928131 | 0.93 | CRBN (0.64) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL27035736 | 0.93 | CRBN (0.64) | CRBNARDDB1ALDH1A1CHRM2 | |
| SCHEMBL29132201 | 0.92 | CRBN (0.69) | CRBNARDDB1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |