Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132038 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL29132130 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL29132404 | 0.94 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL29132098 | 0.94 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL29132096 | 0.94 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL18921646 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL2386800 | 0.91 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL30179036 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL30602886 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTTKDM4E | |
| SCHEMBL26705305 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |