Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910381 | 1.00 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL30358669 | 1.00 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL30358680 | 1.00 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL29133404 | 1.00 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL24602613 | 0.88 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL31103493 | 0.88 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL17210329 | 0.88 | ESR2 (0.46) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL26914838 | 0.86 | ESR2 (0.45) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL29781230 | 0.83 | ESR2 (0.43) | ESR2NR1H2NAMPTABHD6MAPK1 | |
| SCHEMBL12540757 | 0.83 | ESR2 (0.43) | ESR2NR1H2NAMPTABHD6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115835910-A | Hydrogenated isoquinoline or naphthyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2023-03-21 | — | — | CN | disclosed |