Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.63 |
| ▸ | MET | P08581 | 9/20 | 0.63 |
| ▸ | INSR | P06213 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | PAK4 | O96013 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884607 | 1.00 | ALK (0.63) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884816 | 0.95 | ALK (0.63) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884649 | 0.90 | ALK (0.64) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884803 | 0.90 | ALK (0.64) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL2908518 | 0.90 | ALK (0.64) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884561 | 0.88 | ALK (0.62) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884984 | 0.88 | ALK (0.61) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL885228 | 0.88 | ALK (0.61) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL884995 | 0.87 | ALK (0.62) | ALKMETINSRPTK2CDC7 | |
| SCHEMBL2061469 | 0.86 | ALK (0.59) | ALKMETINSRPTK2CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |