Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 4/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24033500 | 1.00 | AAK1 (0.48) | AAK1PDE10AHDAC6JAK2JAK3 | |
| SCHEMBL26712578 | 0.89 | AAK1 (0.49) | AAK1PDE10AHDAC6JAK2JAK3 | |
| SCHEMBL29134759 | 0.89 | AAK1 (0.49) | AAK1PDE10AHDAC6JAK2JAK3 | |
| Lithium Ion SCHEMBL30181681 | 0.87 | AAK1 (0.46) | AAK1PDE10AHDAC6JAK2JAK3 | |
| SCHEMBL2302835 | 0.85 | AAK1 (0.48) | AAK1PDE10AHDAC6JAK2JAK3 | |
| SCHEMBL2173915 | 0.85 | AAK1 (0.48) | AAK1PDE10AHDAC6JAK2JAK3 | |
| SCHEMBL24033406 | 0.83 | AAK1 (0.48) | AAK1PDE10AJAK2JAK3GPR119 | |
| SCHEMBL30665048 | 0.81 | AAK1 (0.53) | AAK1PDE10AJAK2JAK3GPR119 | |
| SCHEMBL24033388 | 0.81 | AAK1 (0.53) | AAK1PDE10AJAK2JAK3GPR119 | |
| SCHEMBL29134277 | 0.81 | AAK1 (0.53) | AAK1PDE10AJAK2JAK3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |