SCHEMBL29134348

SCHEMBL29134348

Cc1cn2cc(N)cc(C)c2n1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.37
ALDH1A1 P00352 2/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
ADORA2A P29274 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
ADORA3 P0DMS8 1/20 0.30
ADORA1 P30542 1/20 0.30
TLR9 Q9NR96 1/20 0.30
TLR8 Q9NR97 1/20 0.30
TLR7 Q9NYK1 1/20 0.30
NOS3 P29474 1/20 0.30
NOS1 P29475 1/20 0.30
NOS2 P35228 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17765426 0.98 RXFP1 (0.36) RXFP1ALDH1A1HPGDHSD17B10ADORA2A
SCHEMBL16339165 0.81 TLR9 (0.41) ALDH1A1HPGDHSD17B10ADORA2ATLR9
SCHEMBL16378071 0.81 NPC1 (0.37) ALDH1A1HPGDHSD17B10ADORA2A
Hydrochloric Acid SCHEMBL16339505 0.79 MAPT (0.36) ALDH1A1HPGDHSD17B10ADORA2A
Hydrochloric Acid SCHEMBL29256940 0.79 TLR9 (0.41) ALDH1A1HPGDHSD17B10ADORA2ATLR9
Hydrochloric Acid SCHEMBL16339034 0.79 TLR9 (0.41) ALDH1A1HPGDHSD17B10ADORA2ATLR9
SCHEMBL12920733 0.79 GRM5 (0.39) RXFP1ALDH1A1HPGDHSD17B10L3MBTL1
SCHEMBL24033542 0.78 MAPT (0.38) ALDH1A1HPGDHSD17B10ADORA2AADORA3
SCHEMBL16378115 0.77 HPGD (0.43) HPGDHSD17B10
Hydrochloric Acid SCHEMBL31600105 0.77 MAPT (0.37) ALDH1A1HPGDHSD17B10ADORA2AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055363-A Compounds and methods for modulating splicing 雷密克斯医疗公司 2026-05-15 CN disclosed
WO-2025111547-A1 2,3-DIHYDROPYROLLOPYRIDINE CARBOXAMIDE COMPOUNDS AND METHODS OF USE THEREOF RGENTA THERAPEUTICS, INC. (US) 2025-05-30 WO disclosed
CN-119948036-A Compounds for the treatment of huntington's disease 渤健马萨诸塞州股份有限公司 2025-05-06 CN disclosed
CN-116997548-A HTT modulators for the treatment of huntington's disease CHDI基金会股份有限公司 2023-11-03 CN disclosed
EP-4149937-A1 HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE CHDI Foundation, Inc. (US) 2023-03-22 EP disclosed