Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29134379 | 1.00 | KCNH2 (0.52) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| SCHEMBL29134617 | 0.99 | KCNH2 (0.51) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| Lithium SCHEMBL30665070 | 0.99 | KCNH2 (0.51) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| SCHEMBL29134615 | 0.99 | KCNH2 (0.51) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| SCHEMBL30390753 | 0.92 | HRH3 (0.49) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| SCHEMBL24817638 | 0.88 | SMO (0.49) | KCNH2MCHR1HRH4ACKR3 | |
| Lithium Ion SCHEMBL30196838 | 0.88 | KCNH2 (0.47) | KCNH2MCHR1HRH4ACKR3HRH3 | |
| SCHEMBL30181756 | 0.88 | SMO (0.49) | KCNH2MCHR1HRH4ACKR3 | |
| SCHEMBL81467 | 0.81 | HRH4 (0.57) | HRH4HRH3 | |
| SCHEMBL25933688 | 0.80 | MAPT (0.50) | ACKR3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |