SCHEMBL29134751

SCHEMBL29134751

C[C@H]1CNC(=O)c2ccc(Br)cc2O1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PBRM1 Q86U86 1/20 0.50
MAPKAPK2 P49137 1/20 0.44
PARP10 Q53GL7 2/20 0.43
PARP11 Q9NR21 1/20 0.43
PARP1 P09874 1/20 0.40
NTRK1 P04629 7/20 0.38
ALK Q9UM73 5/20 0.38
JAK2 O60674 3/20 0.38
NTRK3 Q16288 3/20 0.38
PTK2 Q05397 2/20 0.38
SLC34A2 O95436 1/20 0.38
CD74 P04233 1/20 0.38
ROS1 P08922 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
SRC P12931 1/20 0.38
CYP2C19 P33261 1/20 0.38
NTRK2 Q16620 1/20 0.38
EML4 Q9HC35 1/20 0.38
CDC7 O00311 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30016461 1.00 PBRM1 (0.50) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL30017233 1.00 PBRM1 (0.50) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL24697374 1.00 PBRM1 (0.50) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL23160392 1.00 PBRM1 (0.50) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL29295526 0.83 MAOB (0.46) PARP10PARP11PARP1NTRK1ALK
SCHEMBL29134743 0.81 PARP10 (0.40) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL24699253 0.78 PARP10 (0.40) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL30015575 0.78 PARP10 (0.40) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL30935181 0.78 PARP10 (0.43) PBRM1MAPKAPK2PARP10PARP11PARP1
SCHEMBL30015440 0.78 PARP10 (0.40) PBRM1MAPKAPK2PARP10PARP11PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117120429-A KHK inhibitor 吉利德科学公司 2023-11-24 CN disclosed