Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 11/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200892 | 0.84 | MAPK1 (0.33) | L3MBTL1MAPK1BACE1DPP8DPP9 | |
| SCHEMBL19238955 | 0.82 | MAPT (0.38) | SMN1; SMN2LMNAHPGDMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21072886 | 0.81 | MAPT (0.37) | SMN1; SMN2LMNAHPGDMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19206185 | 0.81 | PTGDR2 (0.35) | LMNAMAPK1KDM4EALDH1A1 | |
| SCHEMBL29134369 | 0.78 | POLB (0.36) | HPGDL3MBTL1BACE1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL29134800 | 0.77 | POLB (0.35) | HPGDBACE1ALDH1A1POLB | |
| SCHEMBL24698740 | 0.75 | KDM1A (0.39) | BACE1ALDH1A1KDM1A | |
| SCHEMBL30016263 | 0.75 | KDM1A (0.39) | BACE1ALDH1A1KDM1A | |
| SCHEMBL29134375 | 0.74 | KDM4E (0.37) | TSHRBACE1KDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL21072882 | 0.74 | DPP8 (0.37) | SMN1; SMN2LMNAHPGDBACE1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |